Sero-diagnostic evaluation of Toxoplasma gondii recombinant Rhoptry antigen 8 expressed in E. coli
نویسندگان
چکیده
منابع مشابه
Production of MAG1 Antigen of Toxoplasma gondii in Escherichia coli
Introduction : Toxoplasmosis is a parasitic infection caused by the protozoan Toxoplasma gondii it leads to serious medical problems in congenitally-infected and immunocompromised individuals, while it is quite harmless in immunocompetent individuals. Toxoplasma tissue cyst matrix protein (MAG1) induces early humoral and cell-mediated immune responses. Previous studies suggested recombinant M...
متن کاملRecombinant MAG1 Protein of Toxoplasma gondii as a Diagnostic Antigen.
The aim of this study was to evaluate the potential diagnostic usefulness of the full-length recombinant Toxoplasma gondii MAG1 protein by determining the levels of specific IgM and IgG antibodies in mouse and human sera obtained from individuals with acute and chronic toxoplasmosis. The obtained results revealed that IgG antibodies against MAG1 are a sensitive and specific marker of T. gondii ...
متن کاملEvaluation of Pichia pastoris-expressed recombinant rhoptry protein 2 of Toxoplasma gondii for its application in diagnosis of toxoplasmosis.
Rhoptry protein 2 (ROP2) of Toxoplasma gondii is a rhoptry-secreted protein that plays a critical role in parasitophorous vacuole membrane formation during invasion. In previous studies, ROP2 has been shown to be efficient in triggering humoral and cell-mediated responses. High immunogenicity of ROP2 makes it a potential candidate for diagnosis and vaccination against toxoplasmosis. In this stu...
متن کاملEvaluating the serological applications of Toxoplasma gondii rhoptry protein 1 (ROP1) antigen
Introduction: Toxoplasma gondii (T. gondii) is distributed worldwide and infects most species. The serious incidence and severe or fatal injury caused by T. gondii infection clearly indicates the necessity for the event of a vaccine. The current study goals were to evaluate serological applications of Toxoplasma gondiirhoptry protein 1 (ROP1) ...
متن کاملProduction of MAG1 Antigen of Toxoplasma gondii in Escherichia coli
Toxoplasma gondii is an obligate intracellular protozoan parasite that can infect human and other warm-blooded animals. Although usually asymptomatic in immunocompetent individuals, toxoplasmosis may reactivate in immunocompromised patients (e.g. AIDS patients and organ transplant recipients) and cause severe diseases such as toxoplasmic encephalitis. Moreover, primary maternal infection can pu...
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ژورنال
عنوان ژورنال: Parasites & Vectors
سال: 2014
ISSN: 1756-3305
DOI: 10.1186/1756-3305-7-297